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Injection: 10 mg/10 mL (1 mg/mL) arsenic trioxide clear solution in a single-dose vial. Purpose This randomized, multicenter, phase III noninferiority trial was designed to test the efficacy and safety of an oral tetra-arsenic tetra-sulfide (As4S4) -containing formula named the Realgar-Indigo naturalis formula (RIF) compared with intravenous arsenic trioxide (ATO) as both induction and maintenance therapies for newly diagnosed acute promyelocytic leukemia (APL). Arsenic Trioxide Phebra must be administered intravenously at a dose of 0.15 mg/kg/day, 5 days per week. Store at 25C (77F); excursions permitted to 15 - 30C (59 - 86F). Contact us Now. Trumac Healthcare is one of leading Arsenic Trioxide Injection Manufacturers Suppliers in India . As an industrial chemical, whose major uses include in the manufacture of wood preservatives, pesticides, and glass. The cost for arsenic trioxide intravenous solution (1 mg/mL) is around $158 for a supply of 10 milliliters, depending on the pharmacy you . 5 WARNINGS AND PRECAUTIONS This may be extended up to four hours if the patient has a vasomotor reaction (lightheadedness, change in blood pressure). Arsenic trioxide prices. arsenic trioxide for injection is indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (apl), which is refractory to or has relapsed from retinoid and anthracycline therapy, and whose apl is characterized by the presence of the t (15;17) translocation or promyelocytic leukemia-retinoic-acid-receptor It slows the growth of cancer cells. ICH GCP. 4 CONTRAINDICATIONS Arsenic Trioxide for Injection is contraindicated in patients who are hypersensitive to arsenic. 2.1 Recommended Dosage for Newly-Diagnosed Low-Risk Acute Promyelocytic Leukemia (APL) A treatment course for patients with newly-diagnosed low-risk APL consists of 1 induction cycle and 4 . (MW > 10-kDa) has been detected in livers and kidneys in rats after an intravenous injection of arsenite . Overview. Hepatotoxicity: Monitor hepatic function tests at least twice weekly during arsenic trioxide injection therapy. Carcinogenesis: Arsenic trioxide is a human carcinogen. Tell your doctor if you drink or have ever drunk large amounts of alcohol, if you have malabsorption syndrome (problems absorbing food), a nutritional deficiency, or if you are taking furosemide (Lasix). According to IQVIA, a leading healthcare data and analytics provider, U.S. annual sales for Arsenic Trioxide Injection, USP, for the 12 months ending October 2020 were approximately $32 million Do not freeze. Patients received Arsenic Trioxide Injection 0.15 mg/kg/day intravenously over 1 to 2 hours until the bone marrow was cleared of . Editorial; Secciones . North Brabant (Dutch: Noord-Brabant [nord brabnt] (); Brabantian: Broabant; Brabantian: [brban]), also unofficially called Brabant, is a province in the south of the Netherlands.It borders the provinces of South Holland and Gelderland to the north, Limburg to the east, Zeeland to the west, and the Flemish provinces of Antwerp and Limburg to the south. Aug 23, 2022 (The Expresswire) -- "Final Report will add the analysis of the impact of COVID-19 on this industry." Global "Arsenic Trioxide Injection . Monitor patients for the development of second primary malignancies. Print Check Drug Interactions. TRISENOX (arsenic trioxide) injection, 1 mg/mL, is the subject of NDA 021248, held by Cephalon, Inc., and initially approved on September 25, 2000. Previous study reported arsenic trioxide could rescue structural p53 mutations, endowing p53 mutations with thermostability and transcriptional activity. Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia, or APL. The turn-on mutations of the KRAS gene, coding a small GTPase coupling growth factor signaling, are contributing to nearly 25% of all human cancers, leading to highly malignant tumors with poor outcomes. Arsenic Trioxide injection is contraindicated in patients with hypersensitivity to arsenic. This study aims to explore the role of AsO in islet xenotransplantation and the action 4 CONTRAINDICATIONS Arsenic trioxide is contraindicated in patients with hypersensitivity to arsenic. Arsenic trioxide is sometimes given in combination with another medicine called tretinoin. Arsenic Trioxide Injection 1mg/ml (10mg/10ml)Technical Specification: Arsenic trioxide injection is used together with another medicine to treat newly-diagnosed low-risk acute promyelocytic leukemia (APL), a type of leukemia (cancer of the blood cells). Speciation of arsenic trioxide metabolites in blood cells and plasma of a patient with acute promyelocytic leukemia 693. of treatment, the concentrations of MA, DMA, and AsIII 1 Dosage Forms and Strengths Injection: 12 mg/6 mL (2 mg/mL) arsenic trioxide clear solution in a single-dose vial. Read more about the prescription drug ARSENIC TRIOXIDE - INJECTION. Arsenic Trioxide Injection. Arsenic trioxide injection may cause encephalopathy (confusion, memory problems, and other difficulties caused by abnormal brain function). Before administering Arsenic Trioxide Injection, assess the QTc interval, correct electrolyte abnormalities, and consider discontinuing drugs known to prolong QTc interval. The underlying mechanisms are not well understood. Arsenic trioxide is usually injected over 1 to 2 hours, but it may be injected over as long as 4 hours if side effects are experienced during the infusion. Arsenic trioxide belongs to the general group of medicines called antineoplastics. TRISENOX (arsenic trioxide) injection is supplied as a sterile, clear, colorless solution in 10 mL glass, single-use ampules. It is usually given once a day for a specific period of time. Arsenic trioxide injection is an injectable solution for intravenous administration supplied as 10 mg/10 mL of arsenic trioxide in single-dose vials. Arsenic trioxide (ATO) is a clinically established drug for the treatment of acute promyelocytic leukemia (APL) . Arsenic Trioxide Injection is indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Brief Summary: TP53 is the most frequently mutated gene in cancer, but these mutations remain therapeutically non-actionable. It is usually given once a day for a specific period of time. Arsenox should be injected into veins over the course of one or a couple of hours. Arsenic trioxide may also be used for other purposes not listed in this medication guide. Some of these may be serious and must be reported to your doctor. . Patients and . Demega Formulations - Offering Worldwide Arsenox (Arsenic Trioxide Injection), Airway, Mumbai at Rs 340/vial in Nagpur, Maharashtra. For the consolidation cycle, the recommended dose of arsenic trioxide injection is 0.15 mg/kg intravenously daily for 25 doses over a period of up to 5 weeks. Do not freeze. IndiaMART. Arsenic Trioxide for Injection Arsenic Trioxide for Injection SteriMax is pleased to announce the launch of Arsenic Trioxide for Injection. Third Party Contract Manufacturing available. The experiment aims to investigate the effects of DSS against ATO-induced cardiotoxicity and its possible mechanism. ADD ANYTHING HERE OR JUST REMOVE IT About us; Contact us; FAQs; Select category Precautions US BOXED WARNINGS: Arsenic Trioxide Injection 10mg/10mL Unit of Sale NDC 14789-0600-10 Size 10mL vials Unit of Sale 10 vials per carton Type Rx Storage Store at 20C to 25C (68F to 77F) . SLOGEN BIOTECH, is the well-known Trader, Exporter, and Supplier of Arsenic Trioxide Injection in Surat. It is usually given once a day for a specific period of time. NDC 63459-600-10 10 mg/10 mL (1 mg/mL) ampule in packages of ten ampules. Arsenic trioxide is usually injected over 1 to 2 hours, but it may be injected over as long as 4 hours if side effects are experienced during the infusion. Arsenic trioxide comes as a solution (liquid) to be injected into a vein by a doctor or nurse in a medical office or clinic. The role of arsenic trioxide (AsO) in inhibiting immune rejection and prolonging islet allograft survival has been identified in islet allotransplantation. Since the growth of normal body cells may also be affected by arsenic trioxide, other unwanted effects will also occur. Cardiac Conduction Abnormalities: Arsenic Trioxide Injection can cause QTc interval prolongation, complete atrioventricular block and torsade de pointes, which can be fatal. Most Common Adverse Reactions: The most common adverse reactions (> 30%) were nausea, cough, fatigue, pyrexia, headache, abdominal pain, vomiting, tachycardia, diarrhea, dyspnea, hypokalemia, leukocytosis, hyperglycemia, hypomagnesemia, insomnia, dermatitis, edema, QTc prolongation, rigors, sore throat, arthralgia, paresthesia, and pruritus. ATO rapidly degrades promyelocytic leukemia-retinoic acid receptor-alpha (PML-RARA) fusion protein and wild-type PML protein, and induces differentiation or apoptosis to exert a dual effect on APL cells [ 20 ]. Arsenic trioxide comes as a solution (liquid) to be injected into a vein by a doctor or nurse in a medical office or clinic. Available Strengths . Arsenic trioxide (As 2 O 3) is used clinically to treat acute promyelocytic leukemia(APL) . How to use Arsenic Trioxide Vial This medication is given by injection into a vein by a health care professional over 2 hours, usually once daily or as directed by your doctor. Follow applicable special handling and disposal procedures. 5 WARNINGS AND PRECAUTIONS Arsenic Trioxide Injection is a hazardous drug. rancho valencia babymoon; wotlk fresh servers blue post; pumpkin spice cookie spread; uc riverside real estate major; in the food web, which organisms are producers? COMMON BRAND NAME (S): Trisenox Also see: Reported side effects; Daily life interactions; Go. For this use it is given by injection into a vein. Most common adverse side effects of Arsenic Trioxide include dizziness, puking, headache, blurred vision, nausea, reactions on injection site and convulsions. Targeting of oncogenic KRAS remains a most challenging task in oncology. Radioactive arsenic-containing compounds and their uses in the treatment of tumorsRadioactive arsenic-containing compounds and their uses in the treatment of tumors . . . It interferes with the growth of cancer cells, which are eventually destroyed. IndiaMART > Pharma Ingredients & Raw Materials > Antineoplastic API > Arsenic Trioxide Powder. Arsenic trioxide is administered via an intravenous (IV) injection over the course of one or two hours. Trisenox Descriptions Arsenic trioxide injection is used together with another medicine (eg, tretinoin) to treat newly-diagnosed low-risk acute promyelocytic leukemia (APL), a type of leukemia (cancer of the blood cells). Arsenic trioxide, sold under the brand name Trisenox among others, is an inorganic compound and medication. . Brand names for arsenic trioxide include Trisenox. injection of the biological sample. Do not use beyond expiration date printed on the label. 5 WARNINGS AND PRECAUTIONS 5.1 Differentiation Syndrome Storage And Handling Store at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F) [See USP Controlled Room Temperature]. 2 (arsenic trioxide) injection 3 For Intravenous Use Only 4 10 mg/10 mL (1 mg/mL) ampule WARNING Experienced Physician and Institution: TRISENOX (arsenic trioxide) injection should be administered under the supervision of a physician who is experienced in the management of patients with acute leukemia. TRISENOX (arsenic trioxide) injection is supplied as a sterile, clear, colorless solution in 10 mL glass, single-dose vials. l19: 21-23. . Eugia US LLC Issues Voluntary Nationwide Recall of Acyclovir Sodium Injection 500 mg per 10 mL (50 mg/mL), Due to the Presence of Particulate Matter. For the induction cycle, the recommended dose of arsenic trioxide injection is 0.15 mg/kg intravenously daily until bone marrow remission or up to a maximum of 60 days. Global "Arsenic Trioxide Injection Market". What happens if you inject arsenic? Active 10mg/10mL Preservative None Latex-Free Yes Inactives Sodium Hydroxide, Hydrochloric Acid Where . Warnings and Precautions To learn more visit the Arsenic Trioxide for Injection product page. It is also used to treat APL in patients who have not responded to other medication regimens. Arsenic Trioxide is the AP rated generic equivalent of the antineoplastic agent Trisenox. 3 DOSAGE FORMS AND STRENGTHS Injection: 12 mg/6 mL (2 mg/mL) arsenic trioxide clear solution in a single-dose vial 4 CONTRAINDICATIONS . Arsenic trioxide, sold under the brand name Trisenox among others, is an inorganic compound and medication. Ingesting high levels of arsenic can result in death. Warnings Consumer information about the medication ARSENIC TRIOXIDE - INJECTION (Trisenox), includes side effects, drug interactions, recommended dosages, and storage information. For this use it is given by . Treatment should be continued for 4 weeks on and 4 weeks off, for a total of 4 cycles. Arsenic trioxide injection is used together with another medicine (eg, tretinoin) to treat newly-diagnosed low-risk acute promyelocytic leukemia (APL), a type of leukemia (cancer of the blood cells). Registro delle prove cliniche. Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient. Arsenic trioxide injection is used in combination with tretinoin to treat acute promyelocytic leukemia (APL) in certain people as a first treatment. For the arsenic trioxide treatment, DMS-273 SCR or shTRIT1 cells were subcutaneously injected in the mouse flanks as described above. 4 CONTRAINDICATIONS Arsenic trioxide injection is contraindicated in patients with hypersensitivity to arsenic. Arsenic Trioxide Injection was investigated in Study PLRXAS01, an open-label, single-arm trial in 40 patients with relapsed or refractory APL who were previously treated with an anthracycline and a retinoid regimen. Danshensu (DSS) has potential applications in the food and healthcare industry to promote cardiovascular health. Get Best Price. A mobile phase was prepared using 10 mM butane sulfonic sodium (special grade), 4 mM malonic acid (special grade), 4 mM tetra- . Arsenic trioxide is a member of the miscellaneous antineoplastics drug class and is commonly used for Acute Promyelocytic Leukemia. Presentation(s): 12 mg/6 mL NDC(s): 55150-366-10 Reference Listed Drug: Trisenox Injection Therapeutic Class: Arsenic trioxide comes as a solution (liquid) to be injected into a vein by a doctor or nurse in a medical office or clinic. Arsenic trioxide is indicated for induction of remission, and consolidation in adult patients with: Newly diagnosed low-to-intermediate risk acute promyelocytic leukaemia (APL) (white blood cell count, 10 x 10 3 /l) in combination with all-trans-retinoic acid (ATRA) Arsenic trioxide is usually injected over 1 to 2 hours, but it may be injected over as long as 4 hours if side effects are experienced during the infusion. We export in ITALY,UAE,SAUDI ARABIA,OMAN,QATAR,PHILIPPINES & AFRICAN Countries Also find Arsenic Trioxide Powder price list | ID: 23249562862. Summary Information ON THIS PAGE: Frequently Asked Questions Drugs Related By Class Learn More Patient Experiences. ARSENIC TRIOXIDE (AR se nik trye OX ide) is a chemotherapy drug. Injection: 12 mg/6 mL (2 mg/mL) arsenic trioxide clear solution in a single-dose vial. It is also used to treat APL in patients who have not responded to other medication regimens. NDC 63459-601-06: 12 mg/6 mL (2 mg/mL) vial in packages of ten vials. If myelosuppression lasts 50 days or longer OR occurs on 2 consecutive cycles, assess a marrow aspirate for remission status. Contraindications Arsenic trioxide is contraindicated in patients with hypersensitivity to arsenic. Arsenic Trioxide for Injection is an injectable solution for intravenous administration supplied as 10 mg /10 mL of arsenic trioxide in single-dose vials. In the case of molecular remission, resume this drug at 1 dose level lower. Arsenic Trioxide injection should be taken under the supervision of qualified health care providers. Cardiotoxicity is a serious side effect of arsenic trioxide (ATO) which hinders its clinical use in cancer chemotherapy. Recently, the specific G12C mutant KRAS inhibitors have been developed but with a limited clinical outcome because they . teva pharmaceutical industries ltd. (nyse and tase: teva) announced that the u.s. food and drug administration (fda) has approved the use of trisenox (arsenic trioxide) injection in combination with tretinoin for the treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia (apl) whose apl is characterized by the presence Relapsed/refractory acute promyelocytic leukaemia (APL) Induction treatment schedule Arsenic has also been linked to increased risks of cancer of the lung , skin , bladder , liver , kidney , and prostate . What is this medication? Based on the vital role of BM microenvironment in maintaining the homeostasis of hematopoietic system, we . Investigators in China introduced arsenic trioxide, alone and in combination chemotherapies, as a cancer therapeutic for patients with APL, achieving notable rates of complete remission. Arsenic trioxide can be used as a single agent and induces complete remissions with only minimal myelosuppression (1). This medicine is used to treat acute promyelocytic leukemia (APL). [Google Scholar] 36. 5 WARNINGS AND PRECAUTIONS Huang XE, Chen J (2006) A clinical study of arsenic trioxide injection in treatment of advanced primary carcinoma of the liver, Journal of basic and clinical oncology. The injection. Store vials between 20C to 25C (68 to 77 F); excursions permitted to 15C to 30C . As a medication, it is used to treat a type of cancer known as acute promyelocytic leukemia. Ten days after injection, the animals were randomized in two groups and treated with vehicle (0.015 N NaOH in saline) or Arsenic Trioxide (A1010, Sigma-Aldrich, St. Louis, MO, USA) diluted in 0.015 N NaOH. Riassunto La leucemia promielocitica acuta definita da una morfologia caratteristica (AML FAB M3/M3v), dalla specifica traslocazione t(15;17) e dai . As an industrial chemical, whose major uses include in the manufacture of wood preservatives, pesticides, and glass. Consider reducing the dose of arsenic trioxide injection by 1 dose level (see Table 3 below). Common side effects of Arsenic Trioxide include: Nausea Cough Fatigue Fever Headache Abdominal pain Vomiting Fast heart rate Diarrhea Shortness of breath Leukocytosis Pain (including bone pain, back pain, muscle pain) Low or high blood potassium ( hypokalemia or hyperkalemia) Low blood magnesium ( hypomagnesemia) High blood sugar ( hyperglycemia) As a medication, it is used to treat a type of cancer known as acute promyelocytic leukemia. Arsenic trioxide injection may cause encephalopathy (confusion, memory problems, and other difficulties caused by abnormal brain . Arsenic Trioxide; Arsenic Trioxide: Solution for injection. Injection: 10 mg/10 mL (1 mg/mL) arsenic trioxide clear solution in a single-dose vial 4 CONTRAINDICATIONS Arsenic trioxide is contraindicated in patients with hypersensitivity to arsenic.

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